Nasal Polyps Treament & Studies

Nasal polyposis (Nose Polyps ) is an inflammatory condition in nasal and paranasal sinus cavities and its pathophysiology is poorly understood. It seems likely that the trace elements such as zinc and selenium may play a critical role in the genesis of inflammatory sinonasal disease. The aim of recent study was to investigate the role of these elements in Nose polyps  and compare these findings with normal nasal mucosa. In this descriptive-analytic cross-sectional study which was done at Imam Khomeini hospital of Ahvaz between July 2018 and June 2019, selenium and zinc levels measured in polyp tissues of 73 patients (48 men and 25 women) and were compared with healthy nasal mucosa of 37 control cases (16 men and 21 women). Hydride generation and flame atom absorption spectroscopy were utilized for selenium and zinc quantifications, consequently. The mean tissue zinc and selenium levels were, respectively, 18.569 μg/g and 68.65 ng/g in patients group and 71.015 μg/g, 249.53 ng/g in cont

Approximately 9% of patients with Nose Polyps undergo surgery annually. Endoscopic sinus surgery (ESS) has been shown to be cost-effective compared to coventional medical therapy. A new natural treatment medical option, the exhalation delivery system with fluticasone (EDS-FLU) was recently approved by FDA for the treatment of nose polyps in adults, and has shown potential in clinical trials (NAVIGATE I/II) to reduce need for ESS by ∼60% after 24 weeks. This study compared the modeled costs and quality adjusted life year (QALY) gains with surgery vs. EDS-FLU over a five-year time horizon in a pooled population of trial participants defined a priori as ESS candidates. The analysis found that nose polyps natural treatments was a dominant choice, producing 0.19 additional QALYs vs. ESS with 19.5% lower total cost . Probabilistic sensitivity analysis found this conclusion to be robust, with 56.6% of simulations showing EDS-FLU to be dominant, and 84.9% of simulations showing natural treatme